Synthesis of (Aminoalkyloxymethyl)dimethylphosphine Oxides

The tertiary phosphine oxides (TPO) comprise a large group of organophosphorus compounds to which a considerable attention in the literature is paid [1-5]. However, only few TPO ’s containing one or more primary amino groups in their mole­ cules are known. Studies on such compounds are limited [6-12]. Because of the high activity of amino groups these compounds can be used as phosphorylation agents for polymers, as well in synthesis of new organophosphorus compounds. That makes them very useful and desired organic reagents. Recently the synthesis of two new sub­ stances that type has been reported by L. Maier [13] and by us [14, 15]: (aminomethyl)dimethylphosphine oxide and bis(aminomethyl)methylphosphine oxide. We have shown as well that these compounds can be used for the synthesis of phosphorus-containing nitrosourea derivatives [16], bifunctional monomers [15], rigid polyurethane foams [14], epoxide amine addition prepolymers and polymers [17], and as organic ligands for co­ ordination compounds with metal ions [18-20]. The present work is a continuation of our studies on the synthesis and investigation of TPO's functionalized with primary aliphatic amino groups. It reports the preparation of a new group of TPO with an amino function in the molecules: (aminoalkyloxymethyl)dimethylphosphine oxides.